Dr Sambhu Nath De: unsung hero
نویسندگان
چکیده
the best way to describe the discovery of cholera toxin by Dr Sambhu Nath De in Calcutta (now known as Kolkata). In a pioneering series of research spanning less than a decade starting from 1952 and culminating in the Nature paper of 19591, De worked relentlessly in search of the elusive toxin that caused the epidemic responsible for the killer disease cholera. De’s discovery of cholera toxin was almost three quarters of a century after Robert Koch first cultured Vibrio cholerae (known as comma bacillus at that time) in Calcutta and 105 years after the microscopic observation of the causative agent of cholera by an Italian anatomist Filippo Pacini and the classic epidemiologic studies of John Snow, a British physician describing the waterborne nature of the disease. Prior to this, it was widely believed that the disease was caused by ‘miasma’ or unpleasant or unhealthy vapours emanating from sewers.
منابع مشابه
Influenza as Observed in the Sambhu Nath Pundit Hospital, Calcutta
The; object of this paper is to record facts observed in influenza cases admitted into the Sambhu Nath Pundit Hospital, Calcutta, in the course of hospital work during the last epidemics which visited Calcutta in quick succession. It does not profess to deal with the subject exhaustively, but to place before the readers matters that proved of general, clinical, bacteriological, diagnostic and t...
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Between 1951 and 1959, Sambhu Nath De made crucial discoveries on the pathogenesis of cholera that changed the course of our understanding of the disease. The discovery that cholera is caused by a potent exotoxin (cholera enterotoxin) affecting intestinal permeability, the demonstration that bacteria-free culture filtrates of Vibrio cholerae were enterotoxic, and the development of a reproducib...
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Abstract. We investigate a variation method where the trial function is generated from the application of a variable operator on a reference function. Two conditions are identified, one for obtaining a maximum and another for a minimum. Although the conditions are easy to understand, the overall formulation is somewhat unusual as each condition gives rise to a two-step variation process. As an ...
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