Dr Sambhu Nath De: unsung hero

نویسندگان

  • G. Balakrish Nair
  • Yoshifumi Takeda
چکیده

the best way to describe the discovery of cholera toxin by Dr Sambhu Nath De in Calcutta (now known as Kolkata). In a pioneering series of research spanning less than a decade starting from 1952 and culminating in the Nature paper of 19591, De worked relentlessly in search of the elusive toxin that caused the epidemic responsible for the killer disease cholera. De’s discovery of cholera toxin was almost three quarters of a century after Robert Koch first cultured Vibrio cholerae (known as comma bacillus at that time) in Calcutta and 105 years after the microscopic observation of the causative agent of cholera by an Italian anatomist Filippo Pacini and the classic epidemiologic studies of John Snow, a British physician describing the waterborne nature of the disease. Prior to this, it was widely believed that the disease was caused by ‘miasma’ or unpleasant or unhealthy vapours emanating from sewers.

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عنوان ژورنال:

دوره 133  شماره 

صفحات  -

تاریخ انتشار 2011